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PEGylation Chemistry Info
  • Example 1 :
    PEG-epoxide pegylates hydroxyl groups at a mild reactivity and is most effectively coupled at higher pH(8.5-9.5). The PEG-epoxide may also pegylate hydoxyl, amine, thiol groups. The PEG-epoxide shows excellent water stability at basic pH.
  • Example 2 :
    PEG-NPC also pegylates hydroxyl groups
  • Example 3 :
    PEG-isocyanate also pegylates hydroxyl groups yielding stable urethane linkage. However, its reactivity may be best exploited for pegylating non-peptide moieties such as drugs, hydroxyl-containing matrices for chromatography, and also to produce biocompatible surfaces.