선바이오(주)

Overview

Lipid nanoparticles (LNPs) have become the leading delivery platform for mRNA and gene-editing therapeutics. However, many LNP formulations face stability challenges during storage, shipping, and freeze-drying, which can lead to particle aggregation, structural degradation, and reduced biological performance.

CloudPEG™ introduces a new stabilization strategy: a dynamic polymer nanonet that forms a protective cloud around the surface of each nanoparticle. This soft, hydrated layer shields LNPs from physical stress and aggregation while preserving their biological delivery function.

The CloudPEG coating is fully tunable. Scientists can control both the thickness of the polymer cloud and the rate at which it dissociates in vivo. After administration, the polymer cloud gradually disperses, allowing the nanoparticle to regain its native surface properties and interact efficiently with target cells.performance.

CloudPEG supports both liquid and lyophilized LNP formulations, enabling flexible storage conditions and facilitating global distribution of RNA-based medicines.

Key Advantages

Enhanced Storage Stability

CloudPEG provides strong steric stabilization that protects LNPs from aggregation and structural disruption during:

• Refrigerated storage
• Freeze–thaw cycles
• Shipping and handling
• Long-term storage

As a result, formulations maintain a consistent particle size distribution and reduced aggregation, improving overall robustness and extending shelf life.

Tunable Protective Cloud

• Adjustable polymer cloud thickness for optimized steric shielding
• Programmable in-vivo dissociation timing
• Balanced protection, circulation behavior, and delivery efficiency

Formulation Compatibility

CloudPEG integrates seamlessly with standard LNP compositions, including formulations containing:

• Ionizable lipids
• Helper phospholipids
• Cholesterol
• PEG-lipids

The platform works with existing LNP manufacturing and production systems. Implementation is simple: CloudPEG can be applied by introducing a small number of ingredients directly into LNP formulations that have already been produced, allowing rapid integration without modifying established manufacturing workflows.

These features allow CloudPEG to provide strong stabilization during storage while enabling the nanoparticle to expose its native surface after administration.

Platform Summary